Prolyl hydroxylase (or procollagen-proline dioxygenase) is an enzyme involved in the production of collagen, acting to hydroxylate proline to hydroxyproline.
It requires vitamin C as a cofactor to keep Iron in the reduced state (Fe2+) but it is not stoichiometrically consumed.[1] α-ketoglutarate serves as reducing agent.
Reaction: Proline + α-ketoglutarate + O2 → 4-hydroxyproline + CO2 + succinate
It is classified under EC 1.14.11.2.
The phenolic compound ethyl protocatechuate is a prolyl 4-hydroxylase inhibitor.[2]
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